Circulating Tumour Cells (CTCs) are cancer cells that have detached from a cancer patient's primary tumour and entered into the blood circulation, a process also known as metastasis.

Growing evidence suggests that CTCs hold significant clinical reference as diagnostic, prognostic and predictive markers in cancer development as they have been shown to be excellent indicators of disease progression and overall survival in patients. Enumerating and studying CTCs may enable clinicians to make timely and life-saving decisions. 

Current methods today rely on complicated techniques such as complex processing, cell-fixing, use of biomarkers and tedious inspections. Moreover, cell viability is lost as such methods damage the cells and prevent retrieval in their native state. 

 

ClearCell® FX- Inertial Focusing

Clearbridge BioMedics’ ClearCell® FX System is a label-free cancer cell enrichment system driven by the CTChip® FR. The CTChip® FR uses inertial focusing to separate the larger cancer cells from other blood components. 

Scientific Reports Publication 


ClearCell® CX- Cell Traps

The CTChip® CS and CTChip® CR encompass detailed research on cell shear stress and fluidic characteristics. This has led to a microfluidic biochip being capable of separating out CTCs from blood.

Using cutting-edge microfluidics and the differences between biomechanical properties of CTCs and blood cells, the CTChip® contains thousands of crescent-shaped cell traps that can isolate CTCs without the use of antibodies or magnetic beads. Gaps between the cell traps are specially designed to trap the less-deformable and larger CTCs while allowing other blood constituents to flow through. As the cells are trapped on the microstructures, reversal of the microfluidic flow allows for cell retrieval.

Clearbridge BioMedics has developed a simple and elegant solution to isolate wholly intact and viable CTCs from patient blood with minimal cell damage while maximising isolation and increased purity.

CTCs isolated on the CTChip® can thereafter be stained on-chip for enumeration using the CTChip® CS or retrieved for further analysis using the CTChip® CR.

 

Disclaimer

Clearbridge BioMedics (hereinafter called 'CBB') disclaims all warranties, both expressed and implied, with respect to the product, including, but not limited to, any implied warranty of merchantability or fitness for a particular purpose. CBB shall not be liable to any person or entity for any medical expenses or any direct, indirect, incidental or consequential damages caused by any use, defect, failure or malfunction of the product, whether a claim for such damages is based upon warranty, contract, tort or otherwise. No person has any authority to bind CBB to any representation or warranty with respect to the product. The exclusions and limitations set out above are not intended to, and should not be construed so as to contravene mandatory provisions of applicable law. If any part or term of this Disclaimer of Warranty is held to be illegal, unenforceable or in conflict with applicable law by court of competent jurisdiction, the validity of the remaining portions of this Disclaimer of Warranty shall not be affected, and all rights and obligations shall be construed and enforced as if this Disclaimer of Warranty did not contain the particular part or term held to be invalid.