Frequently Asked Questions

The ClearCell® FX1 System is an automated, RUO platform used to enrich for Circulating Tumour Cells (CTCs) from patient blood samples. It is a platform for in vitro diagnostics use in Europe.

Patient sample is obtained from a routine blood draw. The blood goes through a quick and simple processing step to remove the red blood cells, and is then passed through the CTChip® FR.

The CTChip® FR is a one-time use microfluidic biochip with a unique spiral design that separates the blood components based on size and inertia, thereby isolating the larger CTCs.

This label-free approach is better able to capture the heterogeneous CTCs, without the use of antibodies, especially for metastatic cancer, where processes like EMT can lead to down regulation of EpCAM expression. The enrichment is very gentle on the cells and the cells spend less than 1 sec within the CTChip® FR. This keeps the cells in their native state and retains high viability. The enriched target rare cells are in a desired condition and state to be integrated into your identified downstream workflow.

The ClearCell® FX1 System has been rigorously tested and validated for human blood samples only.

Since the basis of enrichment in the ClearCell® FX1 System is size and inertia, enriching for cells in other biofluids is feasible with minimal effort in workflow optimisation. Our collaborators have performed preliminary research on other biospecimens such as pleural fluid, urine, mouse blood among other fluid samples.

The ClearCell® FX1 System is compatible with most blood collection tubes, including EDTA, Cell-free DNA BCT® from Streck and CellSave tubes. An EDTA blood collection tube can be used if the blood sample can be processed within 24 hours. Otherwise, Streck Cell-free DNA BCT® would be recommended as the blood sample can be stored up to 72 hours. Blood samples are to be stored at 4 degree celsius.

The choice of blood collection tube will depend on the preferred downstream assays. Please contact us at support@clearbridgebiomedics.com for more information.

All associated reagents and consumables for CTC enrichment on the ClearCell® FX System is provided in the ClearCell® FX1 Run Kit.

Please contact us at sales@clearbridgebiomedics.com for more information.

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