Fluorescence In Situ Hybridisation (FISH)

Fluorescence in situ hybridisation (FISH) is an established cytogenetic technique used in pathology laboratories for tumour profiling and screening of genetic aberrations, such as gene translocation, amplification and deletions. It is also the current gold standard for selection of cancer patient eligible for HER2 and ALK targeted drug therapy. …

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Cell Culture

The emergence of novel technologies offers a new avenue to obtain circulating tumour cells (CTCs) for understanding metastasis. CTCs are extremely rare in circulation and the isolation of intact and viable cells is non-trivial. Use of affinity based methods and magnetic beads based methods could potentially impact cellular phenotypes and viability …

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Molecular Analysis

KRAS is an oncogene with extremely high incidence of mutations. KRAS mutations have been seen in approximately 25% of all cancer types and 30-40% of colorectal cancer (Arrington et al. 2012). It is also associated with poorer prognosis and treatment response in colorectal and lung cancer. As such, there is significant interest in molecular testing of KRAS mutation. …

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Immunofluorescence (IF) / Immunocytochemistry (ICC)

This application note describes the label-free enrichment of CTCs or microemboli from blood sample using the ClearCell® FX platform followed by immunofluorescence assay

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